:: Related Links
:: Cool Sites

Posted by admin on Apr 16, 2018

The TelegraphCancer patients should be given thorough immunotherapy before undergoing surgery to remove dangerous tumours, a new trial suggests. A study on lung cancer patients found that activating the immune system can prompt tumours into spreading friendly T-cells around the body, significantly reducing the chance of cancer returning after surgery. Scientists have hailed the new approach, called “cancer interception”, a “game-changer” potentially capable of stopping the disease in its tracks. Teams are now setting out to trial the method on patients with blood, colon and ovarian cancers in what could be the start of a fundamental shift in treatment of the disease. Oncologists at Johns Hopkins University and the Memorial Sloan Kettering Cancer Center administered the immunotherapy drug nivolumab over several weeks to 21 patients with non-small-cell lung cancer prior to surgery. They found the strategy was not only safe, but that 45 per cent of the patients responded so well there was little evidence of the cancer remaining upon follow-up examinations. Overall, recurrence-free survival at 18 months was 73 per cent. This is compared to a roughly 50 per cent current clinical average. In numbers | Cancer in the UK The team believe the key to the success are the T cells circulating through the patients’ bodies after surgery which attack errant tumour cells and prevent new metastases. They said the nivolumab effectively converted the lung tumours into an “auto-vaccine”, pumping the cancer-killing cells around the body. "That T-cells, activated by immunotherapy prior to surgery, can intercept rogue tumor cells throughout the body after the patient's operation and prevent the cancer from recurring may be a game-changer,” said Dr Sung Poblete, President of Stand Up To Cancer, which funded the research. "This notion of 'cancer interception' has the potential to stop cancer in its tracks.” “We are hopeful that this breakthrough, and the follow-up clinical studies already underway, will translate into a new standard of care." Traditionally, chemotherapy or chemoradiotherapy has been given to lung cancer patients to shrink a large, non-metastasized tumor. Immunotherapeutic agents have then been administered after surgery, but with limited results. The Study is being presented at the American Association for Cancer Research Annual Meeting and published in the New England Journal of Medicine.



Read 2 times | The Telegraph

Related News

Recent News

• Trump jubilant, vengeful as Russia probe ends in win (Mar 26, 2019)

• FAA 'Tentatively' Approves Software Fix to Get the 737 Max 8 Flying Again (Mar 26, 2019)

• The Ford Bronco Will Have a Removable Roof and Doors and Will Go on Sale in Late 2020 (Mar 26, 2019)

• Cruise ship reaches Norway port after near disaster, dramatic rescues (Mar 26, 2019)

• Wary calm as Egyptian-brokered ceasefire ends fighting between Hamas and Israel in Gaza (Mar 26, 2019)

• Everything to Expect From Apple's Big Video and News Event On Monday (Mar 26, 2019)

• How gun laws in a dozen countries compare with New Zealand's new ban on semiautomatic weapons (Mar 26, 2019)

• Republican leader McConnell welcomes more information on Russia probe (Mar 26, 2019)

• US will not 'stand idly' on Russian role in Venezuela: Pompeo (Mar 26, 2019)

• 30+ Healthy Ways To Eat Eggs—And Keep Your Breakfast From Ever Getting Boring (Mar 26, 2019)

• Barr Delivers ‘Principal Conclusions’ of Mueller Report to Congress (Mar 26, 2019)

• Ethiopian Airlines 'believes in' Boeing despite crash: CEO (Mar 26, 2019)

• Police say 1 dead, 5 injured in San Francisco shooting (Mar 26, 2019)

• Children of Isil's caliphate left to toil in squalid refugee camps (Mar 26, 2019)

• You Can't Be Just a Tech Company Anymore, So Apple Became a Bank (Mar 26, 2019)

• American Airlines to cancel 90 flights every day through most of April (Mar 26, 2019)

• Israel, Hamas clash over Gaza, then truce reached (Mar 26, 2019)

• Archeologists believe Norway find is rare Viking ship burial (Mar 26, 2019)

• The Latest: All Viking Sky passengers, crew safe; ship docks (Mar 26, 2019)

• Full text: AG Barr's letter to Congress summarizing the Mueller report (Mar 26, 2019)

• Sony’s mind-blowing $350 noise cancelling headphones are down to $285 if you hurry (Mar 26, 2019)

• All black everything: Ford offers Black Appearance Package for 2019 Ford Rangers (Mar 26, 2019)

• The Ferrari P80/C Is a Two-in-One Track Car and Garage Beauty, and There's Only One (Mar 26, 2019)

• Not enough support yet for third Brexit vote, says UK PM May (Mar 26, 2019)

• Homebuyers to get springtime boost from lower-than-expected mortgage rates (Mar 26, 2019)

:: Search
:: Sponsored Links